Linker Information
General Information of This Linker
| Linker ID |
LIN0VQYIZ
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| Linker Name |
PEG3-benzotriazole-PEG-Val-Cit-PABC
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C58H85N11O14
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| Isosmiles |
CC(C)C(NC(=O)CCOCCOCCOCCOCCNC(=O)CCCCC(=O)N1Cc2ccccc2-c2nnn(CCOCCOCCOCCN)c2-c2ccccc21)C(=O)NC(CCCNC(N)=O)C(=O)Nc1ccc(CO)cc1
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| InChI |
InChI=1S/C58H85N11O14/c1-42(2)53(57(75)64-48(13-9-23-62-58(60)76)56(74)63-45-19-17-43(41-70)18-20-45)65-51(72)21-26-77-30-34-81-38-39-83-36-32-79-28-24-61-50(71)15-7-8-16-52(73)68-40-44-10-3-4-11-46(44)54-55(47-12-5-6-14-49(47)68)69(67-66-54)25-29-80-33-37-82-35-31-78-27-22-59/h3-6,10-12,14,17-20,42,48,53,70H,7-9,13,15-16,21-41,59H2,1-2H3,(H,61,71)(H,63,74)(H,64,75)(H,65,72)(H3,60,62,76)
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| InChIKey |
JRSSUTIMENIHAF-UHFFFAOYSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
1160.381
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Polar area
|
333.4
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Complexity
|
83
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xlogp Value
|
2.8054
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Heavy Count
|
83
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Rot Bonds
|
42
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Hbond acc
|
18
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Hbond Donor
|
8
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Each Antibody-drug Conjugate Related to This Linker
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