Linker Information
General Information of This Linker
| Linker ID |
LIN0VKRVZ
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| Linker Name |
Mal PEG12 based β-glucuronide linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
SGN-CD228A [Phase 1 (discontinued)]
Identified from the Human Clinical Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Related Clinical Trial | |||||
| NCT Number | NCT04042480 | Clinical Status | Phase 1 | ||
| Clinical Description |
A phase 1 study of SGN-CD228A in select advanced solid tumors.
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| Experiment 2 Reporting the Activity Date of This ADC | [3] | ||||
| Patients Enrolled |
Inclusion: Metastatic/unresectable, relapsed/refractory solid tumors (melanoma, mesothelioma, HER2- breast cancer, NSCLC, CRC, PDAC) with prior therapies per tumor type, measurable disease (RECIST v1.1), ECOG 0-1. Exclusion: Recent malignancies, Grade 2+ neuropathy, retinal disease, prior SGN-CD228A/MMAE exposure.
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| Administration Dosage |
SGN-CD228A administered into the vein (IV; intravenously)
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| Related Clinical Trial | |||||
| NCT Number | NCT04042480 | Clinical Status | PHASE1 | ||
| Clinical Description |
A Phase 1 Study of SGN-CD228A in Select Advanced Solid Tumors
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| Primary Endpoint |
The study monitors adverse events (AEs), lab abnormalities, and dose-limiting toxicities (DLTs) over 3.5 years, tracking any untoward medical occurrences in participants administered the investigational drug.
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| Other Endpoint |
Efficacy endpoints include RECIST v1.1/mRECIST response (for mesothelioma), ORR (CR/PR post-treatment), PFS, OS, and DOR. PK analysis covers Cmax, Tmax, AUC (0-last), and Ctrough for acMMAE, free MMAE, and total antibody, alongside ADA incidence, all assessed over 3.5 years.
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Discovered Using Patient-derived Xenograft Model
| Experiment 1 Reporting the Activity Date of This ADC | [2] | ||||
| Efficacy Data | Tumor Growth Inhibition value (TGI) |
75%
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Positive CD228 expression (CD228+++/++) | ||
| Method Description |
SGN-CD228A was evaluated for antitumor activity in melanoma and NSCLC xenograft and PDX models.SGN-CD228A was administered at a single dose of 3.00 mg/kg.
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| In Vivo Model | NSCLC PDX model | ||||
| Experiment 2 Reporting the Activity Date of This ADC | [2] | ||||
| Efficacy Data | Tumor Growth Inhibition value (TGI) |
100%
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Positive CD228 expression (CD228+++/++) | ||
| Method Description |
SGN-CD228A was evaluated for antitumor activity in melanoma and NSCLC xenograft and PDX models.SGN-CD228A was administered at a single dose of 1.00 mg/kg.
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| In Vivo Model | NSCLC PDX model | ||||
Discovered Using Cell Line-derived Xenograft Model
| Experiment 1 Reporting the Activity Date of This ADC | [2] | ||||
| Efficacy Data | Tumor Growth Inhibition value (TGI) |
50%
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Positive CD228 expression (CD228+++/++) | ||
| Method Description |
SGN-CD228A was evaluated for antitumor activity in melanoma and NSCLC xenograft and PDX models.SGN-CD228A was administered at a single dose of 1.00 mg/kg.
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| In Vivo Model | Melanoma CDX model | ||||
| In Vitro Model | Cutaneous melanoma | SK-MEL-5 cells | CVCL_0527 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [2] | ||||
| Efficacy Data | Tumor Growth Inhibition value (TGI) |
62.50%
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Positive CD228 expression (CD228+++/++) | ||
| Method Description |
SGN-CD228A was evaluated for antitumor activity in melanoma and NSCLC xenograft and PDX models.SGN-CD228A was administered at a single dose of 1.00 mg/kg.
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| In Vivo Model | Melanoma CDX model | ||||
| In Vitro Model | Cutaneous melanoma | COLO 853 cells | CVCL_2003 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [2] | ||||
| Efficacy Data | Tumor Growth Inhibition value (TGI) |
100%
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Positive CD228 expression (CD228+++/++) | ||
| Method Description |
SGN-CD228A was evaluated for antitumor activity in melanoma and NSCLC xenograft and PDX models.SGN-CD228A was administered at a single dose of 1.00 mg/kg.
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| In Vivo Model | Squamous NSCLC CDX model | ||||
| In Vitro Model | Lung squamous cell carcinoma | Calu-1 cells | CVCL_0608 | ||
References