Linker Information
General Information of This Linker
| Linker ID |
LIN0VKODR
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|---|---|---|---|---|---|---|
| Name |
JP7615189B2+ADC34+Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C128H191N17O67
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| Isosmiles |
CC(N[C@@H]([C@]1([H])[C@H](O)[C@H](O)CO)[C@@H](O)C[C@@](OC[C@@H]2[C@H](O)[C@H](O)[C@@H](O)C(O[C@H]([C@H]3CO)[C@H](O)[C@@H](NC(C)=O)[C@@H](O3)O[C@H](C(O[C@@H]4C(O)=C(O[C@H]5[C@H](O)[C@@H](NC(C)=O)[C@H](O[C@H]6C(O)C(NC(C)=O)=CO[C@@H]6CO[C@H](O7)[C@@H](O)[C@H](O)[C@H](O)[C@@H]7C)O[C@@H]5CO)O[C@H](CO[C@@H](O8)[C@@H](OC(O9)[C@H](NC(C)=O)[C@@H](O)[C@H](O[C@H]%10[C@H](O)[C@@H](O)[C@@H](O)[C@H](O%10)CO)[C@H]9CO)[C@@H](O)[C@H](O)[C@H]8CO)[C@H]4O)O%11)[C@@H](O)[C@H](O)[C@H]%11CO)O2)(O1)C(NCCOCCOCCOCCN(N=N%12)C(C%13=C(CN%14C(CCC(NCC(NCC(N[C@@H](C(C)C)C(N[C@H](C(NC(C=C%15)=CC=C%15CO)=O)CCCNC(N)=O)=O)=O)=O)=O)=O)C=CC=C%13)=C%12C%16=C%14C=CC=C%16)=O)=O
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| InChI |
InChI=1S/C128H191N17O67/c1-50(2)80(116(186)140-62(17-13-25-131-127(129)188)115(185)139-59-21-19-57(38-146)20-22-59)141-78(163)36-133-77(162)35-132-76(161)23-24-79(164)144-37-58-14-9-10-15-60(58)86-81(61-16-11-12-18-64(61)144)142-143-145(86)27-29-190-31-33-191-32-30-189-28-26-130-126(187)128(34-65(159)82(135-53(5)155)111(212-128)89(167)66(160)39-147)195-49-74-93(171)100(178)105(183)122(204-74)207-108-71(44-152)202-119(85(97(108)175)138-56(8)158)211-114-102(180)92(170)69(42-150)199-125(114)209-112-94(172)73(47-194-124-113(101(179)91(169)68(41-149)198-124)210-118-84(137-55(7)157)96(174)107(70(43-151)201-118)206-121-104(182)99(177)90(168)67(40-148)197-121)203-123(106(112)184)208-109-72(45-153)200-117(83(95(109)173)136-54(6)156)205-110-75(192-46-63(88(110)166)134-52(4)154)48-193-120-103(181)98(176)87(165)51(3)196-120/h9-12,14-16,18-22,46,50-51,62,65-75,80,82-85,87-105,107-114,117-122,124-125,146-153,159-160,165-184H,13,17,23-45,47-49H2,1-8H3,(H,130,187)(H,132,161)(H,133,162)(H,134,154)(H,135,155)(H,136,156)(H,137,157)(H,138,158)(H,139,185)(H,140,186)(H,141,163)(H3,129,131,188)/t51-,62-,65-,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,80-,82+,83+,84+,85+,87+,88?,89+,90-,91+,92+,93-,94+,95+,96+,97+,98+,99-,100-,101-,102-,103-,104+,105+,107+,108+,109+,110+,111+,112-,113-,114-,117-,118?,119-,120+,121-,122?,124-,125?,128+/m0/s1
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| InChIKey |
WYNMNHYEGJRFSI-CJWJNXRXSA-N
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| Pharmaceutical Properties |
Molecule Weight
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3039.988
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Polar area
|
1254.66
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Complexity
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.
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xlogp Value
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-21.0611
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Heavy Count
|
212
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Rot Bonds
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68
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Hbond acc
|
70
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Hbond Donor
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43
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Each Antibody-drug Conjugate Related to This Linker