Linker Information
General Information of This Linker
| Linker ID |
LIN0VIZYN
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| Linker Name |
D4 Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C40H54N10O14
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| Isosmiles |
O=C(N[C@H](C(NCC(CO)=O)=O)CC1=CC=CC=C1)CNC(CNCC(CC(NC(CON)=O)CC(NCC(NCC(N[C@H](C(NCC(CO)=O)=O)CC2=CC=CC=C2)=O)=O)=O)=O)=O
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| InChI |
InChI=1S/C40H54N10O14/c41-64-24-38(61)48-27(14-33(56)43-19-35(58)45-21-37(60)50-32(12-26-9-5-2-6-10-26)40(63)47-17-30(55)23-52)13-28(53)15-42-18-34(57)44-20-36(59)49-31(11-25-7-3-1-4-8-25)39(62)46-16-29(54)22-51/h1-10,27,31-32,42,51-52H,11-24,41H2,(H,43,56)(H,44,57)(H,45,58)(H,46,62)(H,47,63)(H,48,61)(H,49,59)(H,50,60)/t27?,31-,32-/m0/s1
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| InChIKey |
XJCHNIZZTHMAPF-HUSUQQPPSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
898.928
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Polar area
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371.75
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Complexity
|
1835.092618
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xlogp Value
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-6.5408
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Heavy Count
|
64
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Rot Bonds
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31
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Hbond acc
|
16
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Hbond Donor
|
12
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Each Antibody-drug Conjugate Related to This Linker