Linker Information

General Information of This Linker
Linker ID
LIN0VFZNC
Linker Name
Mc-PEG2
Linker Type
Flexible reactive (thiol) linker
Antibody-Linker Relation
Uncleavable
Structure
Formula
C16H27N3O5
Isosmiles
C1=CC(=O)N(C1=O)CCCCCC(=O)NCCOCCOCCN
PubChem CID
121412773
InChI
InChI=1S/C16H27N3O5/c17-7-10-23-12-13-24-11-8-18-14(20)4-2-1-3-9-19-15(21)5-6-16(19)22/h5-6H,1-4,7-13,17H2,(H,18,20)
InChIKey
BRPNMDKROWMZAK-UHFFFAOYSA-N
IUPAC Name
N-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-6-(2,5-dioxopyrrol-1-yl)hexanamide
Pharmaceutical Properties
Molecule Weight
341.4
Polar area
111
Complexity
421
xlogp Value
-0.3
Heavy Count
24
Rot Bonds
14
Hbond acc
6
Hbond Donor
2
Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
Alpha-CD22-HC-A140C-11 [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 3 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Inhibitory Concentration (IC50)
0.03 nM
Positive CD22 expression (CD22+++/++)
Method Description
Seco-CBI-Dimer TDCs Exhibit Potent Antigen-Dependent Antiproliferation Effects in Vitro. All cell-based assay results are reported as the arithmetic mean of at least three separate runs (n = 3).
In Vitro Model Diffuse large B-cell lymphoma WSU-DLCL2 cells CVCL_1902
Experiment 2 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Inhibitory Concentration (IC50)
0.14 nM
Positive CD22 expression (CD22+++/++)
Method Description
Seco-CBI-Dimer TDCs Exhibit Potent Antigen-Dependent Antiproliferation Effects in Vitro. All cell-based assay results are reported as the arithmetic mean of at least three separate runs (n = 3).
In Vitro Model Burkitt lymphoma BJAB cells CVCL_5711
Experiment 3 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Inhibitory Concentration (IC50)
17.00 nM
Positive CD22 expression (CD22+++/++)
Method Description
Seco-CBI-Dimer TDCs Exhibit Potent Antigen-Dependent Antiproliferation Effects in Vitro. All cell-based assay results are reported as the arithmetic mean of at least three separate runs (n = 3).
In Vitro Model T acute lymphoblastic leukemia Jurkat cells CVCL_0065
References
Ref 1 Antibody-Drug Conjugates Derived from Cytotoxic seco-CBI-Dimer Payloads Are Highly Efficacious in Xenograft Models and Form Protein Adducts In Vivo. Bioconjug Chem. 2019 May 15;30(5):1356-1370. doi: 10.1021/acs.bioconjchem.9b00133. Epub 2019 Apr 22.

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