Linker Information
General Information of This Linker
| Linker ID |
LIN0VBCPV
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| Linker Name |
CN113874046B-ADC-2-LINKER
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C61H80N10O16
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| Isosmiles |
CNN(C)CC1=CC2=C(N1CCC(N3CCC(NCCOCCOCCC(N[C@H](CC4=CC=CC=C4)C(N[C@H](CCCCNC(OCC5=CC=C(O[C@@H](O6)[C@@H](O)C(O)=C(O)[C@@H]6C(O)=O)C=C5)=O)C(NC7=CC=C(C=C7)CO)=O)=O)=O)CC3)=O)N=CC=C2
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| InChI |
InChI=1S/C61H80N10O16/c1-62-69(2)37-46-36-43-11-8-26-64-56(43)71(46)30-23-51(74)70-28-21-44(22-29-70)63-27-32-84-34-33-83-31-24-50(73)67-49(35-40-9-4-3-5-10-40)58(79)68-48(57(78)66-45-17-13-41(38-72)14-18-45)12-6-7-25-65-61(82)85-39-42-15-19-47(20-16-42)86-60-54(77)52(75)53(76)55(87-60)59(80)81/h3-5,8-11,13-20,26,36,44,48-49,54-55,60,62-63,72,75-77H,6-7,12,21-25,27-35,37-39H2,1-2H3,(H,65,82)(H,66,78)(H,67,73)(H,68,79)(H,80,81)/t48-,49-,54+,55-,60+/m1/s1
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| InChIKey |
QXEMEXQVUYZBAU-WJLHYAJCSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1209.365
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Polar area
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346.2
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Complexity
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2948.902254
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xlogp Value
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3.3133
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Heavy Count
|
87
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Rot Bonds
|
34
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Hbond acc
|
20
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Hbond Donor
|
11
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Each Antibody-drug Conjugate Related to This Linker