Linker Information
General Information of This Linker
| Linker ID |
LIN0VAZZB
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| Linker Name |
TetraDVP based linker 2c
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C157H237N37O37
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| Isosmiles |
O=C(NCCC(N1C(C=CC=C2)=C2C(N=NN3CCOCCOCCOCCOCCOCCC(NCCCNC(CN(CCNC(CN(CCNC(COCCOCCNC(CCCNC4=NC(C=C)=CC(C=C)=N4)=O)=O)CCNC(COCCOCCNC(CCCNC5=NC(C=C)=CC(C=C)=N5)=O)=O)=O)CCNC(CN(CCNC(COCCOCCNC(CCCNC6=NC(C=C)=CC(CC=C)=N6)=O)=O)CCNC(COCCOCCNC(CCCNC7=NC(C=C)=CC(C=C)=N7)=O)=O)=O)=O)=O)=C3C(C=CC=C8)=C8C1)=O)CCOCCOCCOCCOCCOCCC(N[C@H](C(N[C@@H](CCCNC(N)=O)C(NC9=CC=C(C=C9)CO)=O)=O)C(C)C)=O
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| InChI |
InChI=1S/C157H237N37O37/c1-11-29-128-107-126(18-8)184-157(185-128)176-51-27-38-136(199)171-64-78-220-99-103-231-116-146(209)167-60-70-192(69-59-166-145(208)115-230-102-98-219-77-63-170-135(198)37-26-50-175-156-182-124(16-6)106-125(17-7)183-156)111-142(205)163-56-66-190(65-55-162-141(204)110-191(67-57-164-143(206)113-228-100-96-217-75-61-168-133(196)35-24-48-173-154-178-120(12-2)104-121(13-3)179-154)68-58-165-144(207)114-229-101-97-218-76-62-169-134(197)36-25-49-174-155-180-122(14-4)105-123(15-5)181-155)109-140(203)160-53-28-52-159-137(200)44-72-214-80-84-222-89-93-227-95-91-225-87-83-221-79-71-194-150-129-31-20-19-30-119(129)108-193(132-34-22-21-32-130(132)149(150)188-189-194)147(210)43-54-161-138(201)45-73-215-81-85-223-88-92-226-94-90-224-86-82-216-74-46-139(202)187-148(117(9)10)152(212)186-131(33-23-47-172-153(158)213)151(211)177-127-41-39-118(112-195)40-42-127/h11-22,30-32,34,39-42,104-107,117,131,148,195H,1-8,23-29,33,35-38,43-103,108-116H2,9-10H3,(H,159,200)(H,160,203)(H,161,201)(H,162,204)(H,163,205)(H,164,206)(H,165,207)(H,166,208)(H,167,209)(H,168,196)(H,169,197)(H,170,198)(H,171,199)(H,177,211)(H,186,212)(H,187,202)(H3,158,172,213)(H,173,178,179)(H,174,180,181)(H,175,182,183)(H,176,184,185)/t131-,148-/m0/s1
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| InChIKey |
PHHNQALSQAYRDC-ZBKVAKQYSA-N
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| Pharmaceutical Properties |
Molecule Weight
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3234.845
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Polar area
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919.07
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Complexity
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.
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xlogp Value
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2.2884
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Heavy Count
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231
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Rot Bonds
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139
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Hbond acc
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55
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Hbond Donor
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23
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Each Antibody-drug Conjugate Related to This Linker