Linker Information
General Information of This Linker
| Linker ID |
LIN0UZKNN
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| Linker Name |
WO2023173026A1-ADC-L079-035-Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C36H55N7O12
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| Isosmiles |
CC(C(NC(CCOCCOCCOCCOCCNC(CCN1C(C=CC1=O)=O)=O)=O)C(N[C@@H](CCCNC(N)=O)C(NC2=CC=C(C=C2)CO)=O)=O)C
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| PubChem CID | ||||||
| InChI |
InChI=1S/C36H55N7O12/c1-25(2)33(35(50)41-28(4-3-13-39-36(37)51)34(49)40-27-7-5-26(24-44)6-8-27)42-30(46)12-16-52-18-20-54-22-23-55-21-19-53-17-14-38-29(45)11-15-43-31(47)9-10-32(43)48/h5-10,25,28,33,44H,3-4,11-24H2,1-2H3,(H,38,45)(H,40,49)(H,41,50)(H,42,46)(H3,37,39,51)/t28-,33?/m0/s1
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| InChIKey |
PEGLOOGTSQEDBL-YCIOTGQKSA-N
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| Pharmaceutical Properties |
Molecule Weight
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777.873
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Polar area
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266.05
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Complexity
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1336.864752
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xlogp Value
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-0.9207
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Heavy Count
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55
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Rot Bonds
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29
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Hbond acc
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12
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Hbond Donor
|
7
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Each Antibody-drug Conjugate Related to This Linker