Linker Information
General Information of This Linker
| Linker ID |
LIN0UXZLU
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| Linker Name |
WO2023173026A1-ADC-L079-018-Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C42H67N9O15S
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| Isosmiles |
CN(CCN(C)C(OCC1=CC=C(NC([C@@H](NC([C@@H](NC(CCOCCOCCOCCOCCNC(CCN2C(C(S)CC2=O)=O)=O)=O)C(C)C)=O)CCCNC(N)=O)=O)C=C1)=O)C(O)=O
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| InChI |
InChI=1S/C42H67N9O15S/c1-28(2)36(48-34(53)12-18-62-20-22-64-24-25-65-23-21-63-19-14-44-33(52)11-15-51-35(54)26-32(67)39(51)57)38(56)47-31(6-5-13-45-40(43)58)37(55)46-30-9-7-29(8-10-30)27-66-42(61)50(4)17-16-49(3)41(59)60/h7-10,28,31-32,36,67H,5-6,11-27H2,1-4H3,(H,44,52)(H,46,55)(H,47,56)(H,48,53)(H,59,60)(H3,43,45,58)/t31-,32?,36-/m0/s1
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| InChIKey |
KGIXWWRHJGPOSY-YVIRKVMSSA-N
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| Pharmaceutical Properties |
Molecule Weight
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970.113
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Polar area
|
315.9
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Complexity
|
1682.695341
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xlogp Value
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-0.1025
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Heavy Count
|
67
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Rot Bonds
|
33
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Hbond acc
|
15
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Hbond Donor
|
8
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Each Antibody-drug Conjugate Related to This Linker