Linker Information
General Information of This Linker
| Linker ID |
LIN0UWSJD
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| Linker Name |
CN119326907A Trastuzumab-GDP-N-P1/P2-P1-GGFG-Dxd Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C61H86N16O24
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| Isosmiles |
O=C(NCC(N[C@@H](CC1=CC=CC=C1)C(NCC(O)=O)=O)=O)CNC(CCOCC(N=N2)=CN2COCCN(C(CCC(NC[C@H](O3)[C@@H](O)[C@@H](O)[C@H](O)[C@H]3O)=O)=O)CCOCCOCCN4C=C(N=N4)COCCC(NCC(NCC(N[C@H](C(NCC(O)=O)=O)CC5=CC=CC=C5)=O)=O)=O)=O
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| InChI |
InChI=1S/C61H86N16O24/c78-46(62-27-45-56(90)57(91)58(92)61(95)101-45)11-12-53(85)75(16-21-100-38-77-35-42(72-74-77)37-99-19-14-48(80)64-29-50(82)66-31-52(84)70-44(60(94)68-33-55(88)89)26-40-9-5-2-6-10-40)15-20-96-23-24-97-22-17-76-34-41(71-73-76)36-98-18-13-47(79)63-28-49(81)65-30-51(83)69-43(59(93)67-32-54(86)87)25-39-7-3-1-4-8-39/h1-10,34-35,43-45,56-58,61,90-92,95H,11-33,36-38H2,(H,62,78)(H,63,79)(H,64,80)(H,65,81)(H,66,82)(H,67,93)(H,68,94)(H,69,83)(H,70,84)(H,86,87)(H,88,89)/t43-,44-,45-,56+,57+,58-,61-/m0/s1
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| InChIKey |
BJENDVXPPWQZIG-DSXNHSIYSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1427.447
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Polar area
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554.53
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Complexity
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3157.131466
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xlogp Value
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-7.7632
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Heavy Count
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101
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Rot Bonds
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49
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Hbond acc
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28
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Hbond Donor
|
15
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Each Antibody-drug Conjugate Related to This Linker