Linker Information
General Information of This Linker
| Linker ID |
LIN0UTSXI
|
|||||
|---|---|---|---|---|---|---|
| Linker Name |
T-5 linker
|
|||||
| Linker Type |
Beta-glucuronide based linker
|
|||||
| Antibody-Linker Relation |
Cleavable
|
|||||
| Structure |
|
|||||
| Formula |
C71H74N6O27S2
|
|||||
| Isosmiles |
COC1=CC(C(N2[C@@](C(N3C(OCC4=CC([N+]([O-])=O)=C(O[C@H](O5)[C@H](O)[C@@H](O)[C@H](O)[C@H]5CO)C=C4)=O)O)([H])CC6=C(C2)C=CS6)=O)=C3C=C1OCC7=CC(CN(C)C)=CC(COC8=C(OC)C=C(C9=O)C(N(C(O)[C@]%10([H])CC%11=C(C=CS%11)CN9%10)C(OCC%12=CC=C(O[C@H](O%13)[C@H](O)[C@@H](O)[C@H](O)[C@H]%13C(O)=O)C=C%12)=O)=C8)=C7
|
|||||
| InChI |
InChI=1S/C71H74N6O27S2/c1-72(2)25-35-15-36(31-97-51-21-43-41(19-49(51)95-3)63(85)73-26-38-11-13-105-54(38)23-46(73)65(87)75(43)70(91)99-29-33-5-8-40(9-6-33)101-68-61(84)58(81)59(82)62(104-68)67(89)90)17-37(16-35)32-98-52-22-44-42(20-50(52)96-4)64(86)74-27-39-12-14-106-55(39)24-47(74)66(88)76(44)71(92)100-30-34-7-10-48(45(18-34)77(93)94)102-69-60(83)57(80)56(79)53(28-78)103-69/h5-22,46-47,53,56-62,65-66,68-69,78-84,87-88H,23-32H2,1-4H3,(H,89,90)/t46-,47-,53+,56+,57-,58-,59-,60+,61+,62-,65?,66?,68+,69+/m0/s1
|
|||||
| InChIKey |
SIQGBFOAXAHMRE-SYXVUFHISA-N
|
|||||
| Pharmaceutical Properties |
Molecule Weight
|
1507.522
|
Polar area
|
439.29
|
||
|
Complexity
|
4349.715799
|
xlogp Value
|
3.4889
|
|||
|
Heavy Count
|
106
|
Rot Bonds
|
21
|
|||
|
Hbond acc
|
29
|
Hbond Donor
|
10
|
|||
Each Antibody-drug Conjugate Related to This Linker