Linker Information
General Information of This Linker
| Linker ID |
LIN0UTQVM
|
|||||
|---|---|---|---|---|---|---|
| Linker Name |
T-117 linker
|
|||||
| Linker Type |
Beta-glucuronide based linker
|
|||||
| Antibody-Linker Relation |
Cleavable
|
|||||
| Structure |
|
|||||
| Formula |
C28H35N5O16S
|
|||||
| Isosmiles |
CN(CCOCCN1C=C(N=N1)CCOCCN(C(C=C2)=O)C2=O)C(C3=CC=C(O[C@H]4[C@H](O)[C@@H](O)[C@@H](O)[C@H](O4)C(O)=O)C(OS(O)(=O)=O)=C3)=O
|
|||||
| InChI |
InChI=1S/C28H35N5O16S/c1-31(7-11-46-12-8-32-15-17(29-30-32)6-10-45-13-9-33-20(34)4-5-21(33)35)26(39)16-2-3-18(19(14-16)49-50(42,43)44)47-28-24(38)22(36)23(37)25(48-28)27(40)41/h2-5,14-15,22-25,28,36-38H,6-13H2,1H3,(H,40,41)(H,42,43,44)/t22-,23+,24+,25-,28+/m0/s1
|
|||||
| InChIKey |
NEAWZNLABGKTAH-MHSGGUFMSA-N
|
|||||
| Pharmaceutical Properties |
Molecule Weight
|
729.674
|
Polar area
|
286.91
|
||
|
Complexity
|
1593.113685
|
xlogp Value
|
-2.9964
|
|||
|
Heavy Count
|
50
|
Rot Bonds
|
18
|
|||
|
Hbond acc
|
17
|
Hbond Donor
|
5
|
|||
Each Antibody-drug Conjugate Related to This Linker