Linker Information
General Information of This Linker
| Linker ID |
LIN0URLAJ
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| Linker Name |
Linker of ADC2-60
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C33H52N8O13
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| Isosmiles |
CC([C@H](NC([C@@H](NC(CCCCCN1C(C=CC1=O)=O)=O)CCC(NC[C@@H](O2)[C@@H](O)[C@@H](O)[C@@H]2CC(N)=O)=O)=O)C(N[C@@H](CCCNC(N)=O)C(O)=O)=O)C
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| InChI |
InChI=1S/C33H52N8O13/c1-17(2)27(31(50)39-19(32(51)52)7-6-13-36-33(35)53)40-30(49)18(38-24(44)8-4-3-5-14-41-25(45)11-12-26(41)46)9-10-23(43)37-16-21-29(48)28(47)20(54-21)15-22(34)42/h11-12,17-21,27-29,47-48H,3-10,13-16H2,1-2H3,(H2,34,42)(H,37,43)(H,38,44)(H,39,50)(H,40,49)(H,51,52)(H3,35,36,53)/t18-,19-,20-,21+,27-,28-,29+/m0/s1
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| InChIKey |
YFLSCQKBZUILDI-MBDRIOEOSA-N
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| Pharmaceutical Properties |
Molecule Weight
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768.822
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Polar area
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338.98
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Complexity
|
1333.691461
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xlogp Value
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-3.6237
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Heavy Count
|
54
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Rot Bonds
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24
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Hbond acc
|
12
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Hbond Donor
|
10
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Each Antibody-drug Conjugate Related to This Linker