Linker Information
General Information of This Linker
| Linker ID |
LIN0URDMX
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| Linker Name |
Solubilizing group-PEG8-Hypoxia sensitive linker-Azobenzene
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| Linker Type |
Hypoxia sensitive linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C42H60N6O14
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| Isosmiles |
OCC1=CC=C(C=C1)/N=N/C2=CC=C(C(NCCNC(CCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCN3C(C=CC3=O)=O)=O)=O)=O)C=C2
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| InChI |
InChI=1S/C42H60N6O14/c49-33-34-1-5-36(6-2-34)46-47-37-7-3-35(4-8-37)42(54)45-14-13-43-39(51)12-17-55-19-21-57-23-25-59-27-29-61-31-32-62-30-28-60-26-24-58-22-20-56-18-15-44-38(50)11-16-48-40(52)9-10-41(48)53/h1-10,49H,11-33H2,(H,43,51)(H,44,50)(H,45,54)/b47-46+
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| InChIKey |
UAAJYDDCCSHPOF-CPHIHMHPSA-N
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| Pharmaceutical Properties |
Molecule Weight
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872.97
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Polar area
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243.47
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Complexity
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1553.266474
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xlogp Value
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1.3945
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Heavy Count
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62
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Rot Bonds
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37
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Hbond acc
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16
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Hbond Donor
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4
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
aZO-ADC-8 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.12 nM
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High HER2 expression (HER2+++) | ||
| Method Description |
Cytotoxicity of AZO-ADC-0/4/6/8 to SKOV-3 cells under 0.1 % O2
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| In Vitro Model | Ovarian serous adenocarcinoma | SKOV-3 cells | CVCL_0532 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.34 nM
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High HER2 expression (HER2+++) | ||
| Method Description |
Cytotoxicity of AZO-ADC-0/4/6/8 to BT474-HDR cells under 0.1 % O2
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| In Vitro Model | Invasive breast carcinoma of no special type | BT474-HDR cells | CVCL_0179 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
6.15 nM
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High HER2 expression (HER2+++) | ||
| Method Description |
Cytotoxicity of AZO-ADC-0/4/6/8 toBT474-HDR cells under 20 % O2
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| In Vitro Model | Invasive breast carcinoma of no special type | BT474-HDR cells | CVCL_0179 | ||
| Experiment 4 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
26.65 nM
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High HER2 expression (HER2+++) | ||
| Method Description |
Cytotoxicity of AZO-ADC-0/4/6/8 to SKOV-3 cells under 20 % O2
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| In Vitro Model | Ovarian serous adenocarcinoma | SKOV-3 cells | CVCL_0532 | ||
References