Linker Information
General Information of This Linker
| Linker ID |
LIN0URCJX
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| Linker Name |
ADCProductionexampleNo.7Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C49H72N10O19
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| Isosmiles |
CC(C)[C@H](NC([C@H](CC(N[C@@H](CCO1)C1=O)=O)NC(CCOCCOCCOCCOCCNC([C@@H](N2C(CCC2=O)=O)CNC([C@@H]3CCC(O3)=O)=O)=O)=O)=O)C(N[C@@H](CCCNC(N)=O)C(NC4=CC=C(CO)C=C4)=O)=O
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| InChI |
InChI=1S/C49H72N10O19/c1-29(2)42(47(70)57-32(4-3-15-52-49(50)72)43(66)54-31-7-5-30(28-60)6-8-31)58-44(67)34(26-38(62)55-33-13-18-77-48(33)71)56-37(61)14-17-73-20-22-75-24-25-76-23-21-74-19-16-51-45(68)35(59-39(63)10-11-40(59)64)27-53-46(69)36-9-12-41(65)78-36/h5-8,29,32-36,42,60H,3-4,9-28H2,1-2H3,(H,51,68)(H,53,69)(H,54,66)(H,55,62)(H,56,61)(H,57,70)(H,58,67)(H3,50,52,72)/t32-,33-,34-,35-,36-,42-/m0/s1
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| InChIKey |
HJZDVNDAFHTTKT-JTXZLGNISA-N
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| Pharmaceutical Properties |
Molecule Weight
|
1105.166
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Polar area
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405.95
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Complexity
|
2134.446171
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xlogp Value
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-3.5898
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Heavy Count
|
78
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Rot Bonds
|
36
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Hbond acc
|
19
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Hbond Donor
|
10
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Each Antibody-drug Conjugate Related to This Linker