Linker Information
General Information of This Linker
| Linker ID |
LIN0UQZUO
|
|||||
|---|---|---|---|---|---|---|
| Linker Name |
CN119630431A-ADC-46-LINKER
|
|||||
| Linker Type |
Cathepsin-cleavable linker
|
|||||
| Antibody-Linker Relation |
Cleavable
|
|||||
| Structure |
|
|||||
| Formula |
C29H31N3O10S2
|
|||||
| Isosmiles |
O=C(N1CCOCCOCCC(N[C@@H](CC(O)=O)C(NCC(O)=O)=O)=O)C(SC2=CC=CC=C2)=C(SC3=CC=CC=C3)C1=O
|
|||||
| InChI |
InChI=1S/C29H31N3O10S2/c33-22(31-21(17-23(34)35)27(38)30-18-24(36)37)11-13-41-15-16-42-14-12-32-28(39)25(43-19-7-3-1-4-8-19)26(29(32)40)44-20-9-5-2-6-10-20/h1-10,21H,11-18H2,(H,30,38)(H,31,33)(H,34,35)(H,36,37)/t21-/m0/s1
|
|||||
| InChIKey |
BVJUNUBIISQJRF-NRFANRHFSA-N
|
|||||
| Pharmaceutical Properties |
Molecule Weight
|
645.712
|
Polar area
|
188.64
|
||
|
Complexity
|
1249.107977
|
xlogp Value
|
1.735
|
|||
|
Heavy Count
|
44
|
Rot Bonds
|
19
|
|||
|
Hbond acc
|
10
|
Hbond Donor
|
4
|
|||
Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
WO2024043319A1 35 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.038 nM
|
Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++) | ||
| Method Description |
In vitro cytotoxicity of ADCs in AsPC-1 cells.
|
||||
| In Vitro Model | Pancreatic ductal adenocarcinoma | AsPC-1 cells | CVCL_0152 | ||