Linker Information
General Information of This Linker
| Linker ID |
LIN0UOTLY
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| Linker Name |
BCN-PEG4-EvcPAB linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Formula |
C46H69N7O16
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| Isosmiles |
CC([C@H](NC([C@@H](NC(CCOCCOCCOCCOCCNC(OCC1C2([H])CCC#CCC[C@@]21[H])=O)=O)CCC(O)=O)=O)C(N[C@@H](CCCNC(N)=O)C(NC3=CC=C(C=C3)COC(O)=O)=O)=O)C
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| InChI |
InChI=1S/C46H69N7O16/c1-30(2)40(43(59)52-36(10-7-18-48-44(47)60)41(57)50-32-13-11-31(12-14-32)28-69-46(62)63)53-42(58)37(15-16-39(55)56)51-38(54)17-20-64-22-24-66-26-27-67-25-23-65-21-19-49-45(61)68-29-35-33-8-5-3-4-6-9-34(33)35/h11-14,30,33-37,40H,5-10,15-29H2,1-2H3,(H,49,61)(H,50,57)(H,51,54)(H,52,59)(H,53,58)(H,55,56)(H,62,63)(H3,47,48,60)/t33-,34?,35?,36-,37-,40-/m0/s1
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| InChIKey |
PNYCTDKMVWQPLR-LURUOFNSSA-N
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| Pharmaceutical Properties |
Molecule Weight
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976.091
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Polar area
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330.6
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Complexity
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1772.822227
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xlogp Value
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1.8657
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Heavy Count
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69
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Rot Bonds
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34
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Hbond acc
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14
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Hbond Donor
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9
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
TRSQ-ZP3A-LP4 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.023 nM
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Positive HER2 expression (HER2+++/++) | ||
| Method Description |
The anti-proliferation test was carried out with SK-BR-3 human breast cancer cell line. Cells were grown in McCoy's 5a medium supplemented with 10% FBS,penicillin/streptomycin and L-glutamine.
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||