Linker Information
General Information of This Linker
| Linker ID |
LIN0UMTGL
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| Linker Name |
DBCO-PEG3-amine
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| Linker Type |
Unclear
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| Antibody-Linker Relation |
Unclear
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| Structure |
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| Formula |
C27H33N3O5
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| Isosmiles |
O=C(N(C(C=CC=C1)=C1C#C2)CC3=C2C=CC=C3)CCC(NCCOCCOCCOCCN)=O
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| InChI |
InChI=1S/C27H33N3O5/c28-13-15-33-17-19-35-20-18-34-16-14-29-26(31)11-12-27(32)30-21-24-7-2-1-5-22(24)9-10-23-6-3-4-8-25(23)30/h1-8H,11-21,28H2,(H,29,31)
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| InChIKey |
ZDMKBOWJBWTBIN-UHFFFAOYSA-N
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| Pharmaceutical Properties |
Molecule Weight
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479.577
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Polar area
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103.12
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Complexity
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995.9386465
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xlogp Value
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1.8379
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Heavy Count
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35
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Rot Bonds
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14
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Hbond acc
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6
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Hbond Donor
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2
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
TRSQ-ZP3A-LP21 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.232 nM
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Positive HER2 expression (HER2+++/++) | ||
| Method Description |
The anti-proliferation test was carried out with SK-BR-3 human breast cancer cell line. Cells were grown in McCoy's 5a medium supplemented with 26% FBS,penicillin/streptomycin and L-glutamine.
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||