Linker Information
General Information of This Linker
| Linker ID |
LIN0UKLKK
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| Linker Name |
Linker of ADC2-37
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C43H63N9O17S3
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| Isosmiles |
CC([C@H](NC([C@@H](NC(CCCCCN1C(C=CC1=O)=O)=O)CCC(NC2[C@H](O)[C@H](O)[C@@H](C(NC(O3)[C@H](O)[C@H](O)[C@H]3CO)=O)O2)=O)=O)C(N[C@@H](CCCNC(N)=O)C(NC4=CC=C(CO)C=C4)=O)=O)C.[S].[S].[S]
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| InChI |
InChI=1S/C43H63N9O17.3S/c1-21(2)31(39(65)48-24(7-6-17-45-43(44)67)37(63)46-23-11-9-22(19-53)10-12-23)50-38(64)25(47-27(55)8-4-3-5-18-52-29(57)15-16-30(52)58)13-14-28(56)49-41-35(62)33(60)36(69-41)40(66)51-42-34(61)32(59)26(20-54)68-42;;;/h9-12,15-16,21,24-26,31-36,41-42,53-54,59-62H,3-8,13-14,17-20H2,1-2H3,(H,46,63)(H,47,55)(H,48,65)(H,49,56)(H,50,64)(H,51,66)(H3,44,45,67);;;/t24-,25-,26+,31-,32+,33-,34+,35+,36-,41?,42?;;;/m0.../s1
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| InChIKey |
QOGCDCZLQHRXKX-WWTLOKGTSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1074.224
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Polar area
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406.94
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Complexity
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1915.69307
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xlogp Value
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-2.9954
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Heavy Count
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72
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Rot Bonds
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26
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Hbond acc
|
17
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Hbond Donor
|
14
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Each Antibody-drug Conjugate Related to This Linker