Linker Information
General Information of This Linker
| Linker ID |
LIN0UJAOG
|
|||||
|---|---|---|---|---|---|---|
| Linker Name |
WO2024140449A1+ADC19+Linker
|
|||||
| Linker Type |
Unclear
|
|||||
| Antibody-Linker Relation |
Unclear
|
|||||
| Structure |
|
|||||
| Formula |
C13H26BrN3O6
|
|||||
| Isosmiles |
O=C(NCCN)COCCOCCOCCOCCNC(Br)=O
|
|||||
| InChI |
InChI=1S/C13H26BrN3O6/c14-13(19)17-3-4-20-5-6-21-7-8-22-9-10-23-11-12(18)16-2-1-15/h1-11,15H2,(H,16,18)(H,17,19)
|
|||||
| InChIKey |
DTLCJBBQMFTOPY-UHFFFAOYSA-N
|
|||||
| Pharmaceutical Properties |
Molecule Weight
|
400.27
|
Polar area
|
121.14
|
||
|
Complexity
|
273.7628977
|
xlogp Value
|
-0.7678
|
|||
|
Heavy Count
|
23
|
Rot Bonds
|
16
|
|||
|
Hbond acc
|
7
|
Hbond Donor
|
3
|
|||
Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
wO2024140449A1 ADC20 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | < 5 nM | |||
| Method Description |
A Cell line test onNCI-H1975
|
||||
| In Vitro Model | Lung adenocarcinoma | NCI-H1975 cells | CVCL_1511 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | < 5 nM | |||
| Method Description |
A Cell line test on OE-33
|
||||
| In Vitro Model | Barrett adenocarcinoma, Adenocarcinoma of the esophagus | OE-33 cells | CVCL_0471 | ||