Linker Information
General Information of This Linker
| Linker ID |
LIN0UIEDB
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|---|---|---|---|---|---|---|
| Linker Name |
Anti-Her2-AL1- LP24 linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Formula |
C105H148FN23O32
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| Isosmiles |
NCCOCCOCCOCCN(N=N1)C2=C1CC(OCC(N(CC(NCCOCCOCCC(N[C@H](C(N[C@@H](CCCNC(N)=O)C(NC3=CC=C(C=C3)COC(NCC(NCOCC(N[C@H]4CCC5=C6C4=C7CN(C(C7=NC6=CC(F)=C5C)=C8)C(C(CO9)=C8[C@](CC)(O)C9=O)=O)=O)=O)=O)=O)=O)C(C)C)=O)=O)CC(NCCOCCOCCC(N[C@H](C(N[C@@H](CCCNC(N)=O)C(NC%10=CC=C(C=C%10)COC(NCC(O)=O)=O)=O)=O)C(C)C)=O)=O)=O)CCCC2
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| InChI |
InChI=1S/C105H148FN23O32/c1-7-105(149)73-49-81-94-71(53-128(81)99(143)72(73)58-159-100(105)144)91-75(25-24-70-64(6)74(106)50-79(120-94)90(70)91)119-87(135)59-157-61-116-84(132)51-114-103(147)160-56-65-16-20-67(21-17-65)117-95(139)76(13-10-29-112-101(108)145)121-97(141)92(62(2)3)123-82(130)26-34-150-40-43-153-37-31-110-85(133)54-127(88(136)60-158-69-12-8-9-15-80-78(48-69)125-126-129(80)33-39-155-45-47-156-46-42-152-36-28-107)55-86(134)111-32-38-154-44-41-151-35-27-83(131)124-93(63(4)5)98(142)122-77(14-11-30-113-102(109)146)96(140)118-68-22-18-66(19-23-68)57-161-104(148)115-52-89(137)138/h16-23,49-50,62-63,69,75-77,92-93,149H,7-15,24-48,51-61,107H2,1-6H3,(H,110,133)(H,111,134)(H,114,147)(H,115,148)(H,116,132)(H,117,139)(H,118,140)(H,119,135)(H,121,141)(H,122,142)(H,123,130)(H,124,131)(H,137,138)(H3,108,112,145)(H3,109,113,146)/t69?,75-,76-,77-,92-,93-,105-/m0/s1
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| InChIKey |
RGHMOKZKGYQONA-GKMMJHTKSA-N
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| Pharmaceutical Properties |
Molecule Weight
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2263.466
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Polar area
|
756.73
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Complexity
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.
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xlogp Value
|
-0.45458
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Heavy Count
|
161
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Rot Bonds
|
70
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Hbond acc
|
37
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Hbond Donor
|
19
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Each Antibody-drug Conjugate Related to This Linker
