Linker Information
General Information of This Linker
| Linker ID |
LIN0UGODB
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|---|---|---|---|---|---|---|
| Linker Name |
WO2023156321A1-B4-LINKER
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C27H39N5O8
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| Isosmiles |
CC(C)[C@H](NC(CCOCCNC(CCN1C(CCC1=O)=O)=O)=O)C(N[C@@H](C)C(NC2=CC=C(CO)C=C2)=O)=O
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| InChI |
InChI=1S/C27H39N5O8/c1-17(2)25(27(39)29-18(3)26(38)30-20-6-4-19(16-33)5-7-20)31-22(35)11-14-40-15-12-28-21(34)10-13-32-23(36)8-9-24(32)37/h4-7,17-18,25,33H,8-16H2,1-3H3,(H,28,34)(H,29,39)(H,30,38)(H,31,35)/t18-,25-/m0/s1
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| InChIKey |
CDHVWBMSXWEMLQ-BVZFJXPGSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
561.636
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Polar area
|
183.24
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Complexity
|
994.6229671
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xlogp Value
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-0.1751
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Heavy Count
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40
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Rot Bonds
|
16
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Hbond acc
|
8
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Hbond Donor
|
5
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Each Antibody-drug Conjugate Related to This Linker