Linker Information
General Information of This Linker
| Linker ID |
LIN0UELGP
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| Linker Name |
COT-PEG4-EvcPAB
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C55H82N10O15
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| Isosmiles |
CC([C@H](NC([C@@H](NC(CCOCCOCCOCCOCCNCCOC(CCCCC1)C2=C1C(C3=CC=C(CN)C=C3)=NN=C2C)=O)CCC(O)=O)=O)C(N[C@@H](CCCNC(N)=O)C(NC4=CC=C(C=C4)COC(O)=O)=O)=O)C
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| InChI |
InChI=1S/C55H82N10O15/c1-36(2)49(53(71)62-43(9-7-22-59-54(57)72)51(69)60-41-17-13-39(14-18-41)35-80-55(73)74)63-52(70)44(19-20-47(67)68)61-46(66)21-25-75-28-30-77-32-33-78-31-29-76-26-23-58-24-27-79-45-10-6-4-5-8-42-48(45)37(3)64-65-50(42)40-15-11-38(34-56)12-16-40/h11-18,36,43-45,49,58H,4-10,19-35,56H2,1-3H3,(H,60,69)(H,61,66)(H,62,71)(H,63,70)(H,67,68)(H,73,74)(H3,57,59,72)/t43-,44-,45?,49-/m0/s1
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| InChIKey |
WTRYDHSWCZCKII-IRGKOHFYSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1123.316
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Polar area
|
365.33
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Complexity
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2301.308171
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xlogp Value
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3.38802
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Heavy Count
|
80
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Rot Bonds
|
38
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Hbond acc
|
17
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Hbond Donor
|
10
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Each Antibody-drug Conjugate Related to This Linker