Linker Information
General Information of This Linker
| Linker ID |
LIN0UCWVD
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| Linker Name |
CN110997010A ADC-18 linker
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| Linker Type |
Uncleavable linker
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| Antibody-Linker Relation |
Uncleavable
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| Structure |
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| Formula |
C92H126N20O26S2
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| Isosmiles |
O=C(O)C(NC(C(NC(CCOCCNC(CCN1C(C=CC1=O)=O)=O)=O)CSC(CC2=O)C(N2CC3CCC(C(NCC(N=N4)=CC4CCOCCNC(COCC(N[C@H](CCCCN)C(NC5=CC=C(C=C5)CO)=O)=O)=O)=O)=CC3)=O)=O)CSC(C6=O)CC(N6CC7CCC(C(NCC(N=N8)=CC8CCOCCNC(COCC(N[C@H](CCCCN)C(NC9=CC=C(C=C9)CO)=O)=O)=O)=O)=CC7)=O
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| InChI |
InChI=1S/C92H126N20O26S2/c93-29-3-1-5-69(87(127)100-63-19-11-59(49-113)12-20-63)102-79(119)53-137-51-77(117)96-32-39-134-35-26-65-41-67(108-106-65)45-98-85(125)61-15-7-57(8-16-61)47-111-83(123)43-73(90(111)130)139-55-71(104-76(116)28-37-136-38-31-95-75(115)25-34-110-81(121)23-24-82(110)122)89(129)105-72(92(132)133)56-140-74-44-84(124)112(91(74)131)48-58-9-17-62(18-10-58)86(126)99-46-68-42-66(107-109-68)27-36-135-40-33-97-78(118)52-138-54-80(120)103-70(6-2-4-30-94)88(128)101-64-21-13-60(50-114)14-22-64/h11-15,17,19-24,41-42,57-58,65-66,69-74,113-114H,1-10,16,18,25-40,43-56,93-94H2,(H,95,115)(H,96,117)(H,97,118)(H,98,125)(H,99,126)(H,100,127)(H,101,128)(H,102,119)(H,103,120)(H,104,116)(H,105,129)(H,132,133)/t57?,58?,65?,66?,69-,70-,71?,72?,73?,74?/m1/s1
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| InChIKey |
NNJQGKIIINPULT-XTAKVIJFSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1992.268
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Polar area
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657.63
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Complexity
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.
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xlogp Value
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-0.7094
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Heavy Count
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140
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Rot Bonds
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65
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Hbond acc
|
33
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Hbond Donor
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16
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Each Antibody-drug Conjugate Related to This Linker