Linker Information
General Information of This Linker
| Linker ID |
LIN0UCQGV
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|---|---|---|---|---|---|---|
| Linker Name |
B-57 Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C27H40N2O14
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| Isosmiles |
O=C(NC1=C(O[C@@H]2O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]2O)C=CC(CO)=C1)CCNC(CCOCCOCCOCCC(C)=O)=O
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| InChI |
InChI=1S/C27H40N2O14/c1-16(31)5-8-39-10-12-41-13-11-40-9-6-20(32)28-7-4-21(33)29-18-14-17(15-30)2-3-19(18)42-27-24(36)22(34)23(35)25(43-27)26(37)38/h2-3,14,22-25,27,30,34-36H,4-13,15H2,1H3,(H,28,32)(H,29,33)(H,37,38)/t22-,23-,24+,25-,27+/m0/s1
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| InChIKey |
RPOAUNOKMGCAML-GAYSTUHSSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
616.617
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Polar area
|
239.64
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Complexity
|
1004.86469
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xlogp Value
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-1.6863
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Heavy Count
|
43
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Rot Bonds
|
20
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Hbond acc
|
13
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Hbond Donor
|
7
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Each Antibody-drug Conjugate Related to This Linker