Linker Information
General Information of This Linker
| Linker ID |
LIN0TXPAS
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|---|---|---|---|---|---|---|
| Linker Name |
MC-Val-Cit-RG-11
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C42H58N10O11
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| Isosmiles |
O=C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(COC(NCC2=CC=CN=C2N(CCN3CCOCC3)C(O)=O)=O)C=C1)=O)[C@H](C(C)C)NC(CCCCCN4C(C=CC4=O)=O)=O
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| InChI |
InChI=1S/C42H58N10O11/c1-28(2)36(49-33(53)10-4-3-5-19-51-34(54)15-16-35(51)55)39(57)48-32(9-7-18-45-40(43)58)38(56)47-31-13-11-29(12-14-31)27-63-41(59)46-26-30-8-6-17-44-37(30)52(42(60)61)21-20-50-22-24-62-25-23-50/h6,8,11-17,28,32,36H,3-5,7,9-10,18-27H2,1-2H3,(H,46,59)(H,47,56)(H,48,57)(H,49,53)(H,60,61)(H3,43,45,58)/t32-,36-/m0/s1
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| InChIKey |
AUMBIRWIYYCWIX-IKYOIFQTSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
878.985
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Polar area
|
284.03
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Complexity
|
1841.914291
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xlogp Value
|
1.8226
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Heavy Count
|
63
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Rot Bonds
|
24
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Hbond acc
|
12
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Hbond Donor
|
7
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Each Antibody-drug Conjugate Related to This Linker