Linker Information
General Information of This Linker
| Linker ID |
LIN0TWGPP
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| Linker Name |
COT-PEG3-HOPAS linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Formula |
C31H48N2O16S
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| Isosmiles |
O[C@H]([C@H](O)[C@@H](O)[C@H](OC1=C(OS(=O)(O)=O)C=C(C(NCCOCCOCCOCCNC(COC2CCCCC/C=C\2)=O)=O)C=C1)O3)[C@H]3CO
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| InChI |
InChI=1S/C31H48N2O16S/c34-19-25-27(36)28(37)29(38)31(48-25)47-23-9-8-21(18-24(23)49-50(40,41)42)30(39)33-11-13-44-15-17-45-16-14-43-12-10-32-26(35)20-46-22-6-4-2-1-3-5-7-22/h4,6,8-9,18,22,25,27-29,31,34,36-38H,1-3,5,7,10-17,19-20H2,(H,32,35)(H,33,39)(H,40,41,42)/b6-4-/t22?,25-,27+,28+,29-,31-/m1/s1
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| InChIKey |
VIBXXFLATTZZHG-OJFSEFJESA-N
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| Pharmaceutical Properties |
Molecule Weight
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736.79
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Polar area
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258.1
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Complexity
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1250.702681
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xlogp Value
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-1.1518
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Heavy Count
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50
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Rot Bonds
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21
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Hbond acc
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15
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Hbond Donor
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7
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
TRSQ-ZP3A-LP9 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.22 nM
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Positive HER2 expression (HER2+++/++) | ||
| Method Description |
The anti-proliferation test was carried out with SK-BR-3 human breast cancer cell line. Cells were grown in McCoy's 5a medium supplemented with 15% FBS,penicillin/streptomycin and L-glutamine.
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||