Linker Information
General Information of This Linker
| Linker ID |
LIN0TVPVQ
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| Linker Name |
BCN-PEG4-GGFG linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Formula |
C37H53N5O12
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| Isosmiles |
OC(CNC([C@@H](NC(CNC(CNC(CCOCCOCCOCCOCCNC(OC[C@H]1[C@@]2([H])CCC#CCC[C@]21[H])=O)=O)=O)=O)CC3=CC=CC=C3)=O)=O
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| InChI |
InChI=1S/C37H53N5O12/c43-32(39-23-33(44)40-24-34(45)42-31(36(48)41-25-35(46)47)22-27-8-4-3-5-9-27)12-14-50-16-18-52-20-21-53-19-17-51-15-13-38-37(49)54-26-30-28-10-6-1-2-7-11-29(28)30/h3-5,8-9,28-31H,6-7,10-26H2,(H,38,49)(H,39,43)(H,40,44)(H,41,48)(H,42,45)(H,46,47)/t28-,29+,30-,31-/m0/s1
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| InChIKey |
QCJASOBYXJUFMK-JVVMDBNWSA-N
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| Pharmaceutical Properties |
Molecule Weight
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759.854
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Polar area
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228.95
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Complexity
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1321.034245
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xlogp Value
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-0.2306
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Heavy Count
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54
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Rot Bonds
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27
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Hbond acc
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11
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Hbond Donor
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6
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
TRSQ-ZP3A-LP8 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.065 nM
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Positive HER2 expression (HER2+++/++) | ||
| Method Description |
The anti-proliferation test was carried out with SK-BR-3 human breast cancer cell line. Cells were grown in McCoy's 5a medium supplemented with 14% FBS,penicillin/streptomycin and L-glutamine.
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||
TRSQ-ZP3A-LP19 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.135 nM
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Positive HER2 expression (HER2+++/++) | ||
| Method Description |
The anti-proliferation test was carried out with SK-BR-3 human breast cancer cell line. Cells were grown in McCoy's 5a medium supplemented with 24% FBS,penicillin/streptomycin and L-glutamine.
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||
TRSQ-ZP3A-LP11 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
1.083 nM
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Positive HER2 expression (HER2+++/++) | ||
| Method Description |
The anti-proliferation test was carried out with SK-BR-3 human breast cancer cell line. Cells were grown in McCoy's 5a medium supplemented with 16% FBS,penicillin/streptomycin and L-glutamine.
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||