Linker Information
General Information of This Linker
| Linker ID |
LIN0TUFGH
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| Linker Name |
DVP-based linker 1f
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| Linker Type |
Flexible dual-reactive (amino/thiol) linker
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| Antibody-Linker Relation |
Cleavable
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
Trastuzumab-DVP-linker-MMAE 1 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
1.00 nM
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Positive HER2 expression (HER2+++/++) | ||
| Method Description |
Cells were seeded at 2000 cells per well in black 96-well proliferation plates and dosed with a titration of conjugates for 3 to 5 days, until control untreated cells reached 80 to 90% confluence.
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| In Vitro Model | Invasive breast carcinoma | BT-474 cells | CVCL_0179 | ||
References
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