Linker Information
General Information of This Linker
| Linker ID |
LIN0TQYGO
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| Linker Name |
WO2024020536A1+HER-E-49+Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C27H35N5O8
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| Isosmiles |
O=C(N1CCCCCC(NCC(NCC(N[C@H](C(NCCCC(O)=O)=O)CC2=CC=CC=C2)=O)=O)=O)C=CC1=O
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| InChI |
InChI=1S/C27H35N5O8/c33-21(10-5-2-6-15-32-24(36)12-13-25(32)37)29-17-22(34)30-18-23(35)31-20(16-19-8-3-1-4-9-19)27(40)28-14-7-11-26(38)39/h1,3-4,8-9,12-13,20H,2,5-7,10-11,14-18H2,(H,28,40)(H,29,33)(H,30,34)(H,31,35)(H,38,39)/t20-/m0/s1
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| InChIKey |
ZQOWXYHNMQFZAX-FQEVSTJZSA-N
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| Pharmaceutical Properties |
Molecule Weight
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557.604
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Polar area
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191.08
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Complexity
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1038.515346
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xlogp Value
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-0.5873
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Heavy Count
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40
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Rot Bonds
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18
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Hbond acc
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7
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Hbond Donor
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5
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
HER-E-49 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
. pM
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High HER2 expression (HER2 +++) | ||
| Method Description |
A Cell line test on SKBR-3
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||