Linker Information
General Information of This Linker
| Linker ID |
LIN0TPPST
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| Linker Name |
TW202436324A+ADC-5+Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C26H36N4O8
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| Isosmiles |
C[C@H](NC([C@H](NC(CCOCCOCCN1C(C=CC1=O)=O)=O)C(C)C)=O)C(NC2=CC=C(CO)C=C2)=O
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| InChI |
InChI=1S/C26H36N4O8/c1-17(2)24(26(36)27-18(3)25(35)28-20-6-4-19(16-31)5-7-20)29-21(32)10-12-37-14-15-38-13-11-30-22(33)8-9-23(30)34/h4-9,17-18,24,31H,10-16H2,1-3H3,(H,27,36)(H,28,35)(H,29,32)/t18-,24+/m0/s1
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| InChIKey |
SNHZFZGHXMKDCK-MHECFPHRSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
532.594
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Polar area
|
163.37
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Complexity
|
945.7956141
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xlogp Value
|
0.1112
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Heavy Count
|
38
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Rot Bonds
|
16
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Hbond acc
|
8
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Hbond Donor
|
4
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Each Antibody-drug Conjugate Related to This Linker