Linker Information
General Information of This Linker
| Linker ID |
LIN0TOFSI
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| Linker Name |
MA-FG-P12
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C84H142N6O37
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| Isosmiles |
O=C(CNC(OCC(COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC)(COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC)NC(CNC(C(CC1=CC=CC=C1)NC(C2CCC(CN3C(C=CC3=O)=O)CC2)=O)=O)=O)=O)ON4C(CCC4=O)=O
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| InChI |
InChI=1S/C84H142N6O37/c1-100-16-18-102-20-22-104-24-26-106-28-30-108-32-34-110-36-38-112-40-42-114-44-46-116-48-50-118-52-54-120-56-58-122-60-62-124-68-84(70-126-83(99)86-66-80(96)127-90-78(94)14-15-79(90)95,88-75(91)65-85-82(98)74(64-71-6-4-3-5-7-71)87-81(97)73-10-8-72(9-11-73)67-89-76(92)12-13-77(89)93)69-125-63-61-123-59-57-121-55-53-119-51-49-117-47-45-115-43-41-113-39-37-111-35-33-109-31-29-107-27-25-105-23-21-103-19-17-101-2/h3-7,12-13,72-74H,8-11,14-70H2,1-2H3,(H,85,98)(H,86,99)(H,87,97)(H,88,91)
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| InChIKey |
RYUZUAJPLTXINX-UHFFFAOYSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
1828.065
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Polar area
|
466.67
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Complexity
|
.
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xlogp Value
|
-0.5589
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Heavy Count
|
127
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Rot Bonds
|
91
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Hbond acc
|
37
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Hbond Donor
|
4
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Each Antibody-drug Conjugate Related to This Linker