Linker Information
General Information of This Linker
| Linker ID |
LIN0TNTCS
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| Linker Name |
US11365263B2 ADC#6 linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C37H60N6O13
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| Isosmiles |
CC([C@H](NC(CCOCCOCCOCCOCCOCCOCCN1C(CCC1=O)=O)=O)C(N[C@@H](CCCNC(N)=O)C(NC2=CC=C(C=C2)CO)=O)=O)C
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| InChI |
InChI=1S/C37H60N6O13/c1-27(2)34(36(49)41-30(4-3-12-39-37(38)50)35(48)40-29-7-5-28(26-44)6-8-29)42-31(45)11-14-51-16-18-53-20-22-55-24-25-56-23-21-54-19-17-52-15-13-43-32(46)9-10-33(43)47/h5-8,27,30,34,44H,3-4,9-26H2,1-2H3,(H,40,48)(H,41,49)(H,42,45)(H3,38,39,50)/t30-,34-/m0/s1
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| InChIKey |
RXHFBNJYIVVEGL-NHZFLZHXSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
796.916
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Polar area
|
255.41
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Complexity
|
1249.358937
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xlogp Value
|
-0.1698
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Heavy Count
|
56
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Rot Bonds
|
32
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Hbond acc
|
13
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Hbond Donor
|
6
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Each Antibody-drug Conjugate Related to This Linker