Linker Information
General Information of This Linker
| Linker ID |
LIN0TNLYF
|
|||||
|---|---|---|---|---|---|---|
| Linker Name |
Linker of ADC2-10
|
|||||
| Linker Type |
Cathepsin-cleavable linker
|
|||||
| Antibody-Linker Relation |
Cleavable
|
|||||
| Structure |
|
|||||
| Formula |
C48H70N12O18
|
|||||
| Isosmiles |
CC([C@@H](NC([C@@H](NC(CCCCCN1C(C=CC1=O)=O)=O)CCC(NC[C@@H]2[C@@H](O)[C@@H](O)[C@H](CC(NCC(NCC(NCC(NCC(O)=O)=O)=O)=O)=O)O2)=O)=O)C(N[C@H](CCCNC(N)=O)C(NC3=CC=C(CO)C=C3)=O)=O)C
|
|||||
| InChI |
InChI=1S/C48H70N12O18/c1-26(2)42(47(76)58-29(7-6-17-50-48(49)77)45(74)56-28-11-9-27(25-61)10-12-28)59-46(75)30(57-34(63)8-4-3-5-18-60-39(68)15-16-40(60)69)13-14-33(62)51-20-32-44(73)43(72)31(78-32)19-35(64)52-21-36(65)53-22-37(66)54-23-38(67)55-24-41(70)71/h9-12,15-16,26,29-32,42-44,61,72-73H,3-8,13-14,17-25H2,1-2H3,(H,51,62)(H,52,64)(H,53,65)(H,54,66)(H,55,67)(H,56,74)(H,57,63)(H,58,76)(H,59,75)(H,70,71)(H3,49,50,77)/t29-,30+,31+,32-,42-,43+,44-/m1/s1
|
|||||
| InChIKey |
YJRNHBVMRYUKIY-QNGJVURTSA-N
|
|||||
| Pharmaceutical Properties |
Molecule Weight
|
1103.154
|
Polar area
|
461.62
|
||
|
Complexity
|
2229.265314
|
xlogp Value
|
-5.5132
|
|||
|
Heavy Count
|
78
|
Rot Bonds
|
34
|
|||
|
Hbond acc
|
17
|
Hbond Donor
|
15
|
|||
Each Antibody-drug Conjugate Related to This Linker