Linker Information
General Information of This Linker
| Linker ID |
LIN0TLNIO
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| Linker Name |
CN116137818A-AbT-EXP11-linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C27H34N6O14S
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| Isosmiles |
O=C(O)OCC1=C(S(=O)(O)=O)C=C(NC([C@H](CCCNC(N)=O)NC(C2(NC(CCOCCN3C(C=CC3=O)=O)=O)COC2)=O)=O)C=C1
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| InChI |
InChI=1S/C27H34N6O14S/c28-25(39)29-8-1-2-18(23(37)30-17-4-3-16(13-47-26(40)41)19(12-17)48(42,43)44)31-24(38)27(14-46-15-27)32-20(34)7-10-45-11-9-33-21(35)5-6-22(33)36/h3-6,12,18H,1-2,7-11,13-15H2,(H,30,37)(H,31,38)(H,32,34)(H,40,41)(H3,28,29,39)(H,42,43,44)/t18-/m0/s1
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| InChIKey |
AIJYGXFUOBSMGE-SFHVURJKSA-N
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| Pharmaceutical Properties |
Molecule Weight
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698.664
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Polar area
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299.16
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Complexity
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1487.027215
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xlogp Value
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-1.7834
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Heavy Count
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48
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Rot Bonds
|
18
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Hbond acc
|
12
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Hbond Donor
|
7
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Each Antibody-drug Conjugate Related to This Linker