Linker Information
General Information of This Linker
| Linker ID |
LIN0TKGDN
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| Linker Name |
ADC2-63-1 Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C75H116N22O26
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| Isosmiles |
CC([C@H](NC([C@@H](NC(CCNC(CN1C(C=CC1=O)=O)=O)=O)CCC(NC[C@@H](O2)[C@@H](O)[C@@H](O)[C@@H]2CC(N(CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)C(N[C@@H](CCCNC(N)=O)C(NC3=CC=C(C=C3)CO)=O)=O)C
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| InChI |
InChI=1S/C75H116N22O26/c1-44(2)69(74(121)83-47(16-15-26-79-75(77)122)72(119)81-46-19-17-45(43-98)18-20-46)84-73(120)48(82-53(101)25-27-78-54(102)31-97-55(103)23-24-56(97)104)21-22-52(100)80-29-50-71(118)70(117)49(123-50)28-57(105)86(4)32-59(107)88(6)34-61(109)90(8)36-63(111)92(10)38-65(113)94(12)40-67(115)96(14)42-68(116)95(13)41-66(114)93(11)39-64(112)91(9)37-62(110)89(7)35-60(108)87(5)33-58(106)85(3)30-51(76)99/h17-20,23-24,44,47-50,69-71,98,117-118H,15-16,21-22,25-43H2,1-14H3,(H2,76,99)(H,78,102)(H,80,100)(H,81,119)(H,82,101)(H,83,121)(H,84,120)(H3,77,79,122)/t47-,48-,49-,50+,69-,70-,71+/m0/s1
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| InChIKey |
HVIBXPVGRIDPQU-DZSWTWLWSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1741.881
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Polar area
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623.83
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Complexity
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.
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xlogp Value
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-11.1306
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Heavy Count
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123
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Rot Bonds
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49
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Hbond acc
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26
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Hbond Donor
|
12
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Each Antibody-drug Conjugate Related to This Linker