Linker Information
General Information of This Linker
| Linker ID |
LIN0TJHCN
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| Linker Name |
B-49 Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C34H49N5O16
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| Isosmiles |
O=C(NC1=C(O[C@@H]2O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]2O)C=CC(CO)=C1)CCNC(CCOCCOCCOCCNC(CN3C(C(C)=C(C)C(N3C)=O)=O)=O)=O
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| InChI |
InChI=1S/C34H49N5O16/c1-19-20(2)32(48)39(38(3)31(19)47)17-26(43)36-9-11-52-13-15-53-14-12-51-10-7-24(41)35-8-6-25(42)37-22-16-21(18-40)4-5-23(22)54-34-29(46)27(44)28(45)30(55-34)33(49)50/h4-5,16,27-30,34,40,44-46H,6-15,17-18H2,1-3H3,(H,35,41)(H,36,43)(H,37,42)(H,49,50)/t27-,28-,29+,30-,34+/m0/s1
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| InChIKey |
VGPCZICDZZEEHS-MIZDCASSSA-N
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| Pharmaceutical Properties |
Molecule Weight
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783.785
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Polar area
|
295.67
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Complexity
|
1677.333363
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xlogp Value
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-3.37176
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Heavy Count
|
55
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Rot Bonds
|
22
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Hbond acc
|
17
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Hbond Donor
|
8
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Each Antibody-drug Conjugate Related to This Linker