Linker Information
General Information of This Linker
| Linker ID |
LIN0TFFTA
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|---|---|---|---|---|---|---|
| Linker Name |
ThioBridge-PEG24-Val-Ala-PAB
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C83H143Br2N7O32
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| Isosmiles |
COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)C(CCC(=O)NC(C(=O)NC(CCCNC(N)=O)C(=O)Nc1ccc(CO)cc1)C(C)C)NC(=O)c1ccc(C(=O)C(CBr)CBr)cc1
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| InChI |
InChI=1S/C83H143Br2N7O32/c1-68(2)77(82(99)91-74(5-4-16-88-83(86)100)81(98)89-73-12-6-69(67-93)7-13-73)92-76(94)15-14-75(90-79(96)71-10-8-70(9-11-71)78(95)72(65-84)66-85)80(97)87-17-18-102-21-22-104-25-26-106-29-30-108-33-34-110-37-38-112-41-42-114-45-46-116-49-50-118-53-54-120-57-58-122-61-62-124-64-63-123-60-59-121-56-55-119-52-51-117-48-47-115-44-43-113-40-39-111-36-35-109-32-31-107-28-27-105-24-23-103-20-19-101-3/h6-13,68,72,74-75,77,93H,4-5,14-67H2,1-3H3,(H,87,97)(H,89,98)(H,90,96)(H,91,99)(H,92,94)(H3,86,88,100)
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| InChIKey |
LPYQQMBHYWGDNW-UHFFFAOYSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1910.882
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Polar area
|
459.44
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Complexity
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1907.81444
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xlogp Value
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2.5034
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Heavy Count
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124
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Rot Bonds
|
93
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Hbond acc
|
32
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Hbond Donor
|
8
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Each Antibody-drug Conjugate Related to This Linker