Linker Information
General Information of This Linker
| Linker ID |
LIN0TESUX
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| Linker Name |
CN110997010A ADC-19 linker
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| Linker Type |
Uncleavable linker
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| Antibody-Linker Relation |
Uncleavable
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| Structure |
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| Formula |
C134H210N20O47S2
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| Isosmiles |
O=C(O)C(NC(C(NC(CCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCN1C(C=CC1=O)=O)=O)=O)CSC(CC2=O)C(N2CC3CCC(C(NCC(N=N4)=CC4CCOCCOCCOCCOCCOCCOCCOCCOCCNC(COCC(N[C@H](CCCCN)C(NC5=CC=C(C=C5)CO)=O)=O)=O)=O)=CC3)=O)=O)CSC(C6=O)CC(N6CC7CCC(C(NCC(N=N8)=CC8CCOCCOCCOCCOCCOCCOCCOCCOCCNC(COCC(N[C@H](CCCCN)C(NC9=CC=C(C=C9)CO)=O)=O)=O)=O)=CC7)=O
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| InChI |
InChI=1S/C134H210N20O47S2/c135-29-3-1-5-111(129(169)142-105-19-11-101(91-155)12-20-105)144-121(161)95-200-93-119(159)138-32-39-180-45-51-186-57-63-192-69-75-198-80-77-194-71-65-188-59-53-182-47-41-176-35-26-107-83-109(150-148-107)87-140-127(167)103-15-7-99(8-16-103)89-153-125(165)85-115(132(153)172)202-97-113(146-118(158)28-37-178-43-49-184-55-61-190-67-73-196-79-82-197-74-68-191-62-56-185-50-44-179-38-31-137-117(157)25-34-152-123(163)23-24-124(152)164)131(171)147-114(134(174)175)98-203-116-86-126(166)154(133(116)173)90-100-9-17-104(18-10-100)128(168)141-88-110-84-108(149-151-110)27-36-177-42-48-183-54-60-189-66-72-195-78-81-199-76-70-193-64-58-187-52-46-181-40-33-139-120(160)94-201-96-122(162)145-112(6-2-4-30-136)130(170)143-106-21-13-102(92-156)14-22-106/h11-15,17,19-24,83-84,99-100,107-108,111-116,155-156H,1-10,16,18,25-82,85-98,135-136H2,(H,137,157)(H,138,159)(H,139,160)(H,140,167)(H,141,168)(H,142,169)(H,143,170)(H,144,161)(H,145,162)(H,146,158)(H,147,171)(H,174,175)/t99?,100?,107?,108?,111-,112-,113?,114?,115?,116?/m1/s1
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| InChIKey |
SGYNBLJNNLVGFN-WESRVQEUSA-N
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| Pharmaceutical Properties |
Molecule Weight
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2917.381
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Polar area
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851.46
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Complexity
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.
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xlogp Value
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-0.3608
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Heavy Count
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203
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Rot Bonds
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128
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Hbond acc
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54
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Hbond Donor
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16
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Each Antibody-drug Conjugate Related to This Linker