Linker Information
General Information of This Linker
| Linker ID |
LIN0TEDED
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|---|---|---|---|---|---|---|
| Linker Name |
DEVD linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C36H47N5O14
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| Isosmiles |
CC([C@H](NC([C@H](CCC(O)=O)CC([C@@H](NC(CCCCCN1C(C=CC1=O)=O)=O)CC(O)=O)=O)=O)C(N[C@@H](CC(O)=O)C(NC2=CC=C(CO)C=C2)=O)=O)C
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| InChI |
InChI=1S/C36H47N5O14/c1-20(2)33(36(55)39-25(18-32(51)52)35(54)37-23-10-7-21(19-42)8-11-23)40-34(53)22(9-14-30(47)48)16-26(43)24(17-31(49)50)38-27(44)6-4-3-5-15-41-28(45)12-13-29(41)46/h7-8,10-13,20,22,24-25,33,42H,3-6,9,14-19H2,1-2H3,(H,37,54)(H,38,44)(H,39,55)(H,40,53)(H,47,48)(H,49,50)(H,51,52)/t22-,24+,25+,33+/m1/s1
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| InChIKey |
GYVBHQUYRBFGPK-PPHHSPOBSA-N
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| Pharmaceutical Properties |
Molecule Weight
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773.793
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Polar area
|
302.98
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Complexity
|
1556.109774
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xlogp Value
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0.1028
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Heavy Count
|
55
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Rot Bonds
|
25
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Hbond acc
|
11
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Hbond Donor
|
8
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Each Antibody-drug Conjugate Related to This Linker