Linker Information
General Information of This Linker
| Linker ID |
LIN0TBXFS
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| Linker Name |
CN119630431A-ADC-29-LINKER
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C27H29N3O8S2
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| Isosmiles |
NC(C[C@H](NC(CCOCCOCCN1C(C(SC2=CC=CC=C2)=C(SC3=CC=CC=C3)C1=O)=O)=O)C(O)=O)=O
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| InChI |
InChI=1S/C27H29N3O8S2/c28-21(31)17-20(27(35)36)29-22(32)11-13-37-15-16-38-14-12-30-25(33)23(39-18-7-3-1-4-8-18)24(26(30)34)40-19-9-5-2-6-10-19/h1-10,20H,11-17H2,(H2,28,31)(H,29,32)(H,35,36)/t20-/m0/s1
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| InChIKey |
PDFHOSUQGZQUDM-FQEVSTJZSA-N
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| Pharmaceutical Properties |
Molecule Weight
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587.676
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Polar area
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165.33
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Complexity
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1123.614127
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xlogp Value
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2.0195
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Heavy Count
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40
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Rot Bonds
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17
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Hbond acc
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9
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Hbond Donor
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3
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
WO2024043319A1 18 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.047 nM
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Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++) | ||
| Method Description |
In vitro cytotoxicity of ADCs in AsPC-1 cells.
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| In Vitro Model | Pancreatic ductal adenocarcinoma | AsPC-1 cells | CVCL_0152 | ||