Linker Information
General Information of This Linker
| Linker ID |
LIN0TBHQY
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| Linker Name |
ADC2-64-1 Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C87H136N26O30
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| Isosmiles |
CC([C@H](NC([C@@H](NC(CCNC(CN1C(C=CC1=O)=O)=O)=O)CCC(NC[C@@H](O2)[C@@H](O)[C@@H](O)[C@@H]2CC(N(CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)C(N[C@@H](CCCNC(N)=O)C(NC3=CC=C(C=C3)CO)=O)=O)C
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| InChI |
InChI=1S/C87H136N26O30/c1-52(2)81(86(141)95-55(20-19-30-91-87(89)142)84(139)93-54-23-21-53(51-114)22-24-54)96-85(140)56(94-61(117)29-31-90-62(118)35-113-63(119)27-28-64(113)120)25-26-60(116)92-33-58-83(138)82(137)57(143-58)32-65(121)98(4)36-67(123)100(6)38-69(125)102(8)40-71(127)104(10)42-73(129)106(12)44-75(131)108(14)46-77(133)110(16)48-79(135)112(18)50-80(136)111(17)49-78(134)109(15)47-76(132)107(13)45-74(130)105(11)43-72(128)103(9)41-70(126)101(7)39-68(124)99(5)37-66(122)97(3)34-59(88)115/h21-24,27-28,52,55-58,81-83,114,137-138H,19-20,25-26,29-51H2,1-18H3,(H2,88,115)(H,90,118)(H,92,116)(H,93,139)(H,94,117)(H,95,141)(H,96,140)(H3,89,91,142)/t55-,56-,57-,58+,81-,82-,83+/m0/s1
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| InChIKey |
NNUBUPCGAUWEIH-JEWNLZKUSA-N
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| Pharmaceutical Properties |
Molecule Weight
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2026.197
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Polar area
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705.07
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Complexity
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.
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xlogp Value
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-13.297
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Heavy Count
|
143
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Rot Bonds
|
57
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Hbond acc
|
30
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Hbond Donor
|
12
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Each Antibody-drug Conjugate Related to This Linker