Linker Information
General Information of This Linker
| Linker ID |
LIN0TAANW
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|---|---|---|---|---|---|---|
| Linker Name |
IG-L-45 linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C60H81FN14O21
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| Isosmiles |
CN(CC(N(CC(N(C)CC(N(C)CC(N(C)CC(N(CC(N(CC(N(C)CC(N(C)CC(N(CC(O)=O)C)=O)=O)=O)C)=O)C)=O)=O)=O)=O)C)=O)C(CCCOC1=C(F)C(N2C(C=CC2=O)=O)=CC=C1CCC(N[C@@H](C)C(NCC(NC3=CC=C(C=C3)COC(O)=O)=O)=O)=O)=O
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| InChI |
InChI=1S/C60H81FN14O21/c1-37(59(92)62-25-43(77)64-40-18-14-38(15-19-40)36-96-60(93)94)63-42(76)21-17-39-16-20-41(75-45(79)22-23-46(75)80)57(61)58(39)95-24-12-13-44(78)65(2)26-47(81)66(3)27-48(82)67(4)28-49(83)68(5)29-50(84)69(6)30-51(85)70(7)31-52(86)71(8)32-53(87)72(9)33-54(88)73(10)34-55(89)74(11)35-56(90)91/h14-16,18-20,22-23,37H,12-13,17,21,24-36H2,1-11H3,(H,62,92)(H,63,76)(H,64,77)(H,90,91)(H,93,94)/t37-/m0/s1
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| InChIKey |
BZUDNEJYPUJBCI-QNGWXLTQSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1353.383
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Polar area
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420.84
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Complexity
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3179.534085
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xlogp Value
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-3.5305
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Heavy Count
|
96
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Rot Bonds
|
36
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Hbond acc
|
19
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Hbond Donor
|
5
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Each Antibody-drug Conjugate Related to This Linker