Linker Information
General Information of This Linker
| Linker ID |
LIN0SXLQS
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| Linker Name |
LL2 linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C31H45N7O10
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| Isosmiles |
CC([C@H](NC(C)=O)C(N[C@@H](CCCNC(N)=O)C(NC1=CC(OCCOCCNC(CCN2C(C=CC2=O)=O)=O)=C(C=C1)CO)=O)=O)C
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| InChI |
InChI=1S/C31H45N7O10/c1-19(2)28(35-20(3)40)30(45)37-23(5-4-11-34-31(32)46)29(44)36-22-7-6-21(18-39)24(17-22)48-16-15-47-14-12-33-25(41)10-13-38-26(42)8-9-27(38)43/h6-9,17,19,23,28,39H,4-5,10-16,18H2,1-3H3,(H,33,41)(H,35,40)(H,36,44)(H,37,45)(H3,32,34,46)/t23-,28-/m0/s1
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| InChIKey |
MADYFAQIOJGNFH-FIPFOOKPSA-N
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| Pharmaceutical Properties |
Molecule Weight
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675.74
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Polar area
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247.59
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Complexity
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1271.034344
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xlogp Value
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-0.9619
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Heavy Count
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48
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Rot Bonds
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21
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Hbond acc
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10
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Hbond Donor
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7
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
MORAb-003 ADC2 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
4.7 nM
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High FRA expression (FRA +++) | ||
| Method Description |
Use crystal violet analysis to evaluate the in vitro efficacy of the prepared ADCs. Initially screen all MORAb003 ADCs on IGROV1 (FRi (+++)) and SJSA - 1 (FReg (-)) cells.
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| In Vitro Model | Osteosarcoma | SJSA-1 cells | CVCL_1697 | ||