Linker Information
General Information of This Linker
| Linker ID |
LIN0SWBXK
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| Linker Name |
CN119630431A-ADC-36-LINKER
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C33H38N4O12S2
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| Isosmiles |
C[C@@H](NC(CCOCCOCCN1C(C(SC2=CC=CC=C2)=C(SC3=CC=CC=C3)C1=O)=O)=O)C(N[C@@H](CO)C(N[C@H](C(O)=O)CC(O)=O)=O)=O
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| InChI |
InChI=1S/C33H38N4O12S2/c1-20(29(42)36-24(19-38)30(43)35-23(33(46)47)18-26(40)41)34-25(39)12-14-48-16-17-49-15-13-37-31(44)27(50-21-8-4-2-5-9-21)28(32(37)45)51-22-10-6-3-7-11-22/h2-11,20,23-24,38H,12-19H2,1H3,(H,34,39)(H,35,43)(H,36,42)(H,40,41)(H,46,47)/t20-,23+,24+/m1/s1
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| InChIKey |
HPKZSZKXSXGYOL-QDSKXPNFSA-N
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| Pharmaceutical Properties |
Molecule Weight
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746.817
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Polar area
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237.97
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Complexity
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1459.251401
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xlogp Value
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0.6006
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Heavy Count
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51
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Rot Bonds
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22
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Hbond acc
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12
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Hbond Donor
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6
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
WO2024043319A1 25 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.057 nM
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Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++) | ||
| Method Description |
In vitro cytotoxicity of ADCs in AsPC-1 cells.
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| In Vitro Model | Pancreatic ductal adenocarcinoma | AsPC-1 cells | CVCL_0152 | ||