Linker Information
General Information of This Linker
| Linker ID |
LIN0SVDBQ
|
|||||
|---|---|---|---|---|---|---|
| Linker Name |
CN110997010A ADC-26 linker
|
|||||
| Linker Type |
Cathepsin-cleavable linker
|
|||||
| Antibody-Linker Relation |
Cleavable
|
|||||
| Structure |
|
|||||
| Formula |
C52H72N8O18S2
|
|||||
| Isosmiles |
C[C@H](NC([C@@H](NC(CCCCCN1C(CCC1=O)=O)=O)C(C)C)=O)C(NC2=CC=C(COC(NC(CSC(CC3=O)C(N3CCCCCC(O)=O)=O)C(NC(C(O)=O)CSC(C4=O)CC(N4CCCCCC(O)=O)=O)=O)=O)C=C2)=O
|
|||||
| InChI |
InChI=1S/C52H72N8O18S2/c1-30(2)45(57-38(61)13-7-4-10-22-58-39(62)20-21-40(58)63)48(72)53-31(3)46(70)54-33-18-16-32(17-19-33)27-78-52(77)56-34(28-79-36-25-41(64)59(49(36)73)23-11-5-8-14-43(66)67)47(71)55-35(51(75)76)29-80-37-26-42(65)60(50(37)74)24-12-6-9-15-44(68)69/h16-19,30-31,34-37,45H,4-15,20-29H2,1-3H3,(H,53,72)(H,54,70)(H,55,71)(H,56,77)(H,57,61)(H,66,67)(H,68,69)(H,75,76)/t31-,34?,35?,36?,37?,45-/m0/s1
|
|||||
| InChIKey |
SHHXGODLMRTUMA-YUVZJHTCSA-N
|
|||||
| Pharmaceutical Properties |
Molecule Weight
|
1161.32
|
Polar area
|
378.77
|
||
|
Complexity
|
2336.734839
|
xlogp Value
|
2.1556
|
|||
|
Heavy Count
|
80
|
Rot Bonds
|
36
|
|||
|
Hbond acc
|
17
|
Hbond Donor
|
8
|
|||
Each Antibody-drug Conjugate Related to This Linker