Linker Information
General Information of This Linker
| Linker ID |
LIN0SUMWX
|
|||||
|---|---|---|---|---|---|---|
| Linker Name |
CN118001423A+ADC5+Linker
|
|||||
| Linker Type |
Unclear
|
|||||
| Antibody-Linker Relation |
Unclear
|
|||||
| Structure |
|
|||||
| Formula |
C41H72BrN5O16
|
|||||
| Isosmiles |
COCCOCCOCCOCCOCCOCCOCCOCCOC1=C(NC([C@@H](NC(CNC(CCOCCOCCNC(CBr)=O)=O)=O)CCCCN)=O)C=CC(CO)=C1
|
|||||
| InChI |
InChI=1S/C41H72BrN5O16/c1-53-12-13-56-16-17-57-18-19-58-20-21-59-22-23-60-24-25-61-26-27-62-28-29-63-37-30-34(33-48)5-6-35(37)47-41(52)36(4-2-3-8-43)46-40(51)32-45-38(49)7-10-54-14-15-55-11-9-44-39(50)31-42/h5-6,30,36,48H,2-4,7-29,31-33,43H2,1H3,(H,44,50)(H,45,49)(H,46,51)(H,47,52)/t36-/m0/s1
|
|||||
| InChIKey |
HADZIZRQPDFPIA-BHVANESWSA-N
|
|||||
| Pharmaceutical Properties |
Molecule Weight
|
970.95
|
Polar area
|
264.18
|
||
|
Complexity
|
1226.425096
|
xlogp Value
|
-0.0768
|
|||
|
Heavy Count
|
63
|
Rot Bonds
|
45
|
|||
|
Hbond acc
|
17
|
Hbond Donor
|
6
|
|||
Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
CN118001423A ADC5 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | < 50 nM | High NECTIN4 expression (NECTIN4 +++) | ||
| Method Description |
A Cell line test on MDA-MB-468
|
||||
| In Vitro Model | Breast adenocarcinoma | MDA-MB-468 cells | CVCL_0419 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | < 50 nM | High NECTIN4 expression (NECTIN4 +++) | ||
| Method Description |
A Cell line test on SW-780
|
||||
| In Vitro Model | Mouse melanoma | SW-780 cells | CVCL_1728 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | ≈ 50≈200 nM | High NECTIN4 expression (NECTIN4 +++) | ||
| Method Description |
A Cell line test on MCF-7
|
||||
| In Vitro Model | Invasive breast carcinoma | MCF-7 cells | CVCL_0031 | ||
| Experiment 4 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | < 50 nM | High NECTIN4 expression (NECTIN4 +++) | ||
| Method Description |
A Cell line test on LNCAP
|
||||
| In Vitro Model | Prostate carcinoma | LNCaP cells | CVCL_0395 | ||
| Experiment 5 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | < 50 nM | High NECTIN4 expression (NECTIN4 +++) | ||
| Method Description |
A Cell line test on BxPC-3
|
||||
| In Vitro Model | Pancreatic ductal adenocarcinoma | BxPC-3 cells | CVCL_0186 | ||
References