Linker Information
General Information of This Linker
| Linker ID |
LIN0SQDNI
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| Linker Name |
AU2023279443A1, Example A22, Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C50H78N12O23P2
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| Isosmiles |
CN(CCNC(CCOCCOCCOP(O)(OCCNC([C@H](CNC(CCP(O)(O)=O)=O)N1C(C=CC1=O)=O)=O)=O)=O)CC(N[C@@H](CC(N[C@@H]2C(OCC2)=O)=O)C(N[C@H](C(N[C@@H](CCCNC(N)=O)C(NC3=CC=C(C=C3)CO)=O)=O)C(C)C)=O)=O
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| InChI |
InChI=1S/C50H78N12O23P2/c1-31(2)44(48(73)59-34(5-4-15-54-50(51)75)45(70)56-33-8-6-32(30-63)7-9-33)60-46(71)36(27-40(66)57-35-12-20-83-49(35)74)58-41(67)29-61(3)18-16-52-38(64)13-19-81-22-23-82-24-25-85-87(79,80)84-21-17-53-47(72)37(62-42(68)10-11-43(62)69)28-55-39(65)14-26-86(76,77)78/h6-11,31,34-37,44,63H,4-5,12-30H2,1-3H3,(H,52,64)(H,53,72)(H,55,65)(H,56,70)(H,57,66)(H,58,67)(H,59,73)(H,60,71)(H,79,80)(H3,51,54,75)(H2,76,77,78)/t34-,35-,36-,37-,44-/m0/s1
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| InChIKey |
NCVCWMXRUZWMHC-LKOFGUHASA-N
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| Pharmaceutical Properties |
Molecule Weight
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1277.183
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Polar area
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506.82
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Complexity
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2533.532466
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xlogp Value
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-4.8032
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Heavy Count
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87
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Rot Bonds
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42
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Hbond acc
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21
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Hbond Donor
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14
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
AU2023279443A1 Example A22 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Cell growth inhibition rate (%) | > 14% | Positive HER2 expression (HER2+++/++) | ||
| Method Description |
Cell growth inhibition test was carried out on HER2-positive human gastric cancer cell line (NCI-N87), the cells were treated with a test compound or an anti-HER2 antibody (trastuzumab) at a concentration of 100 ng/mL. The cells were cultured for 6 days, then CellTiter-Glo was added and the luminescence amount was measured.
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| In Vitro Model | Gastric tubular adenocarcinoma | NCI-N87 cells | CVCL_1603 | ||