Linker Information
General Information of This Linker
| Linker ID |
LIN0SQBWO
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| Linker Name |
COT-GG linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Formula |
C14H21N3O4
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| Isosmiles |
O=C(NCC(NCC(N)=O)=O)COC1C#CCCCCC1
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| InChI |
InChI=1S/C14H21N3O4/c15-12(18)8-16-13(19)9-17-14(20)10-21-11-6-4-2-1-3-5-7-11/h11H,1-4,6,8-10H2,(H2,15,18)(H,16,19)(H,17,20)
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| InChIKey |
VFKYTCDFLRNCCP-UHFFFAOYSA-N
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| Pharmaceutical Properties |
Molecule Weight
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295.339
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Polar area
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110.52
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Complexity
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413.0546019
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xlogp Value
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-0.9432
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Heavy Count
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21
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Rot Bonds
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7
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Hbond acc
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4
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Hbond Donor
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3
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
TRSQ-ZP3A-LP17-Ve [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.098 nM
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Positive HER2 expression (HER2+++/++) | ||
| Method Description |
The anti-proliferation test was carried out with SK-BR-3 human breast cancer cell line. Cells were grown in McCoy's 5a medium supplemented with 38% FBS,penicillin/streptomycin and L-glutamine.
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||