Linker Information
General Information of This Linker
| Linker ID |
LIN0SPLLV
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|---|---|---|---|---|---|---|
| Linker Name |
Anti-Her2-AL1- LP38 linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C100H160N22O38
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| Isosmiles |
NCCOCCOCCOCCN(N=N1)C2=C1CC(OCC(NCCOCCOCCC(NC(COCCC(NCCOCCOCCC(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CCCNC(N)=O)C(NC3=CC=C(C=C3)COC(NCC(O)=O)=O)=O)=O)C(C)C)=O)=O)=O)COCCC(NCCOCCOCCC(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CCCNC(N)=O)C(NC4=CC=C(C=C4)COC(NCC(O)=O)=O)=O)=O)C(C)C)=O)=O)=O)=O)=O)CCCC2
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| InChI |
InChI=1S/C100H160N22O38/c1-65(2)89(95(141)116-73(10-7-31-107-97(102)143)91(137)112-69-17-13-67(14-18-69)60-159-99(145)109-58-87(133)134)118-93(139)75(21-23-85(129)130)114-82(126)28-38-148-48-51-151-43-33-104-79(123)25-40-156-62-71(111-81(125)27-37-147-47-53-153-45-35-106-84(128)64-158-72-9-5-6-12-78-77(57-72)120-121-122(78)36-46-154-54-56-155-55-50-150-42-30-101)63-157-41-26-80(124)105-34-44-152-52-49-149-39-29-83(127)115-76(22-24-86(131)132)94(140)119-90(66(3)4)96(142)117-74(11-8-32-108-98(103)144)92(138)113-70-19-15-68(16-20-70)61-160-100(146)110-59-88(135)136/h13-20,65-66,71-76,89-90H,5-12,21-64,101H2,1-4H3,(H,104,123)(H,105,124)(H,106,128)(H,109,145)(H,110,146)(H,111,125)(H,112,137)(H,113,138)(H,114,126)(H,115,127)(H,116,141)(H,117,142)(H,118,139)(H,119,140)(H,129,130)(H,131,132)(H,133,134)(H,135,136)(H3,102,107,143)(H3,103,108,144)/t72?,73-,74-,75-,76-,89-,90-/m0/s1
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| InChIKey |
FPYQECVQHBGSFH-CDMPAHHPSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
2278.496
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Polar area
|
852.79
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Complexity
|
.
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xlogp Value
|
-3.3962
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Heavy Count
|
160
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Rot Bonds
|
90
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Hbond acc
|
38
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Hbond Donor
|
23
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Each Antibody-drug Conjugate Related to This Linker
